Targeted Solid Lipid Nanoparticles Formulation for Colon Cancer Treatment and Cytotoxicity Assessment Using HT29 Cell Line
نویسندگان
چکیده
Background: Several pharmacological effects have been attributed to thymol. However, limitations such as low solubility in water, bioavailability, and high volatility limited its use. Objectives: The present study aimed prepare characterize thymol-loaded solid lipid nanoparticles (SLNs) improve the efficacy of Methods: Thymol-loaded SLNs were characterized by atomic force microscopy (AFM), differential scanning calorimetry (DSC), Fourier transformed infrared spectroscopy (FT-IR). Cytotoxicity hemolysis assay also performed. Results: vitro drug release showed a sustained manner. Also, loaded with thymol higher cytotoxicity than free thymol, results indicated blood biocompatibility SLNs. Conclusions: As nanocarriers, can open new avenue for improving cancer treatment.
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ژورنال
عنوان ژورنال: Jundishapur Journal of Natural Pharmaceutical Products
سال: 2023
ISSN: ['1735-7780', '2228-7876']
DOI: https://doi.org/10.5812/jjnpp-135987